ꯇꯤꯔꯖꯦꯄꯦꯇꯤꯗ ꯑꯁꯤ GLP-1 (ꯒ꯭ꯂꯨꯀꯣꯒꯟ-ꯂꯥꯏꯛ ꯄꯦꯄꯇꯤꯛ-1) ꯑꯃꯁꯨꯡ ꯖꯤ.ꯑꯥꯏ.ꯄꯤ.(ꯒ꯭ꯂꯨꯀꯣꯖ-ꯗꯤꯄꯦꯟꯗꯦꯟꯇ ꯏꯅꯁꯨꯂꯤꯅꯣꯠꯔꯣꯄꯤꯛ ꯄꯣꯂꯤꯄꯦꯄꯇꯤꯗ)ꯒꯤ ꯗ꯭ꯌꯨꯑꯦꯜ ꯔꯤꯁꯦꯄꯇꯔ ꯑꯦꯒꯣꯅꯤꯁ꯭ꯠ ꯑꯃꯅꯤ:
1. ꯀ꯭ꯔꯣꯅꯤꯛ ꯑꯣꯖꯟ ꯃꯦꯅꯦꯖꯃꯦꯟꯇ .
ꯑꯦꯛꯁꯅꯒꯤ ꯃꯦꯀꯥꯅꯤꯖꯝ:
ꯃꯁꯤꯅꯥ ꯑꯦꯄꯦꯇꯥꯏꯠ ꯊꯤꯡꯏ ꯑꯃꯁꯨꯡ ꯁꯦꯟꯠꯔꯦꯜ ꯅꯔꯚ ꯁꯤꯁ꯭ꯇꯦꯃꯒꯤ ꯈꯨꯠꯊꯥꯡꯗꯥ ꯀꯦꯂꯣꯔꯤ ꯏꯅꯇꯦꯛ ꯍꯟꯊꯍꯜꯂꯤ, ꯑꯗꯨꯒꯥ ꯃꯦꯇꯥꯕꯣꯂꯤꯛ ꯏꯟꯗꯤꯀꯦꯇꯔꯁꯤꯡ. ꯐꯒꯠꯍꯜꯂꯤ
ꯏꯐꯤꯁꯤꯑꯦꯟꯁꯤ: ꯱.
ꯑꯣꯕꯦꯁꯤꯇꯤ ꯂꯩꯕꯥ ꯄꯦꯁꯦꯟꯇꯁꯤꯡ (BMI 30ꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯋꯥꯡꯕꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯥꯟꯅꯕꯥ): ꯆꯥꯡꯆꯠꯇꯥ ꯑꯔꯨꯝꯕꯥ 15%{2}}% (ꯈ꯭ꯕꯥꯏꯗꯒꯤ ꯌꯥꯝꯅꯥ ꯗꯣꯖ 15 mg/week).
ꯑꯣꯚꯔꯋꯦꯠ + ꯀꯃꯞꯂꯤꯀꯦꯁꯅꯁꯤꯡ (ꯕꯤ.ꯑꯦꯝ.ꯑꯥꯏ. ꯲꯷ꯗꯒꯤ ꯍꯦꯟꯅꯥ ꯅꯠꯠꯔꯒꯥ ꯃꯥꯟꯅꯕꯥ): ꯃꯁꯤ ꯍꯥꯏꯄꯔꯇꯦꯟꯁꯟ ꯑꯃꯁꯨꯡ ꯗꯤꯁꯂꯤꯄꯤꯗꯦꯃꯤꯌꯥ ꯂꯩꯕꯥ ꯑꯅꯥꯕꯁꯤꯡꯗꯁꯨ ꯑꯦꯞꯂꯤꯀꯦꯕꯜ ꯑꯣꯏ.
2. ꯇꯥꯏꯞ ꯲ ꯗꯥꯏꯕꯦꯇꯤꯁ
ꯑꯦꯛꯁꯅꯒꯤ ꯃꯦꯀꯥꯅꯤꯖꯝ:
GLP-1 ꯔꯤꯁꯦꯞꯇꯔꯁꯤꯡ → ꯏꯅꯁꯨꯂꯤꯟ ꯁꯦꯛꯔꯦꯁꯟ ꯄ꯭ꯔꯣꯃꯣꯠ ꯇꯧꯕꯥ, ꯒ꯭ꯂꯨꯀꯣꯒꯟ ꯊꯤꯡꯕꯥ, ꯑꯃꯁꯨꯡ ꯒ꯭ꯌꯥꯁ꯭ꯠꯔꯤꯛ ꯏꯝꯄꯣꯔꯠ ꯇꯧꯕꯥ ꯊꯦꯡꯊꯍꯅꯕꯥ.
ꯖꯤ.ꯑꯥꯏ.ꯄꯤ.ꯒꯤ ꯔꯤꯁꯦꯄꯇꯔꯁꯤꯡ ꯑꯦꯛꯇꯤꯕ ꯑꯣꯏꯍꯅꯕꯥ → ꯏꯅꯁꯨꯂꯤꯟ ꯁꯦꯟꯁꯤꯇꯤꯕꯤꯇꯤ ꯍꯦꯅꯒꯠꯍꯅꯕꯥ ꯑꯃꯁꯨꯡ ꯐꯦꯠ ꯑꯦꯛꯌꯨꯃꯨꯂꯦꯁꯟ ꯍꯟꯊꯍꯅꯕꯥ.
ꯏꯐꯤꯁꯤꯑꯦꯟꯁꯤ: ꯱.
HBA1C (ꯒ꯭ꯂꯥꯏꯀꯣꯁꯥꯏꯂꯦꯇꯦꯗ ꯍꯦꯃꯣꯒ꯭ꯂꯣꯕꯤꯟ) (1.8%-2.4%) ꯍꯟꯊꯍꯅꯕꯥ ꯑꯁꯤ ꯌꯥꯝꯅꯥ ꯍꯟꯊꯍꯜꯂꯤ꯫
ꯑꯦꯁꯤꯁ꯭ꯇꯦꯟꯇ ꯑꯣꯖꯟ ꯍꯟꯊꯕꯥ (ꯀ꯭ꯂꯤꯅꯤꯀꯦꯜ ꯇ꯭ꯔꯥꯏꯑꯦꯂꯁꯤꯡꯗꯥ ꯂꯩꯕꯥ ꯄꯦꯁꯦꯟꯇꯁꯤꯡꯅꯥ ꯆꯥꯡꯆꯠꯇꯥ 5%-11% ꯑꯔꯨꯝꯕꯥ ꯍꯟꯊꯈꯤ).
ꯑꯦꯞꯂꯤꯀꯦꯕꯜ ꯑꯣꯏꯕꯥ ꯃꯤꯁꯤꯡ:
ꯇꯥꯏꯞ 2 ꯗꯥꯏꯑꯦꯕꯦꯇꯤꯖ ꯂꯩꯕꯥ ꯑꯍꯂꯁꯤꯡ (ꯆꯥꯎꯕꯥ ꯑꯃꯁꯨꯡ ꯑꯦꯛꯁꯔꯁꯥꯏꯖ ꯇꯧꯕꯥ ꯃꯊꯧ ꯇꯥꯕꯥ).
3. ꯔꯤꯁꯔꯆꯇꯥ ꯄꯣꯇꯦꯟꯁꯤꯑꯦꯜ ꯁꯤꯖꯤꯟꯅꯕꯁꯤꯡ
ꯅꯟ-ꯑꯦꯂꯀꯣꯍꯣꯂꯤꯛ ꯁ꯭ꯇꯦꯇꯣꯍꯦꯄꯥꯇꯥꯏꯇꯤꯁ (NASH): ꯂꯤꯚꯔ ꯏꯅꯐ꯭ꯂꯦꯃꯦꯁꯟ ꯑꯃꯁꯨꯡ ꯐꯥꯏꯕ꯭ꯔꯣꯁꯤꯁ ꯐꯒꯠꯍꯅꯕꯥ.꯫
ꯀꯥꯔꯗꯤꯑꯣꯚꯥꯁ꯭ꯀꯨꯂꯥꯔ ꯄ꯭ꯔꯣꯇꯦꯛꯁꯟ: ꯇꯥꯏꯞ 2 ꯗꯥꯏꯑꯦꯕꯦꯇꯤꯖ ꯂꯩꯕꯥ ꯑꯅꯥꯕꯁꯤꯡꯗꯥ ꯀꯥꯔꯗꯤꯑꯣꯚꯥꯁ꯭ꯀꯨꯂꯥꯔ ꯔꯤꯁ꯭ꯛ ꯍꯟꯊꯍꯅꯕꯥ ꯌꯥꯏ (GLP-1 ꯗ꯭ꯔꯒꯁꯤꯡꯒꯥ ꯃꯥꯟꯅꯕꯥ).
ꯄꯣꯂꯤꯁꯤꯁ꯭ꯇꯤꯛ ꯑꯣꯕꯦꯔꯤ ꯁꯤꯟꯗꯣꯝ (PCOS): ꯑꯔꯨꯝꯕꯥ ꯍꯟꯊꯍꯅꯕꯒꯤ ꯈꯨꯠꯊꯥꯡꯗꯥ ꯍꯣꯔꯃꯣꯟ ꯏꯃꯕꯦꯂꯦꯟꯁ ꯐꯒꯠꯍꯅꯕꯥ .
ꯄ꯭ꯔꯗꯛꯇ ꯗꯤꯁꯞꯂꯦ
ꯑꯦꯅꯥꯂꯥꯏꯁꯤꯁ ꯔꯤꯄꯣꯔꯠ ꯇꯧꯕꯥ
ꯀꯁ꯭ꯇꯃꯔꯁꯤꯡꯒꯤ ꯐꯤꯗꯕꯦꯛ
ꯐꯦꯛꯇꯔꯤꯒꯤ ꯃꯇꯥꯡꯗꯥ ꯋꯥꯔꯣꯜ ꯄꯤꯕꯥ
ꯄꯦꯀꯦꯖꯤꯡ ꯑꯃꯁꯨꯡ ꯇ꯭ꯔꯥꯟꯁꯄꯣꯔꯇꯦꯁꯟ
ꯑꯩꯈꯣꯌꯒꯤ ꯀꯥꯟꯅꯕꯁꯤꯡ .
ꯑꯋꯥꯡꯕꯥ ꯊꯥꯛꯀꯤ, ꯀꯝꯄꯤꯇꯤꯇꯤꯕ ꯄ꯭ꯔꯥꯏꯁ, ꯃꯇꯤꯛ ꯆꯥꯕꯥ ꯁ꯭ꯇꯣꯛ ꯑꯃꯁꯨꯡ ꯌꯥꯝꯅꯥ ꯊꯨꯅꯥ ꯄꯤꯕꯥ ꯀꯝꯄꯤꯇꯤꯇꯤꯕ ꯄ꯭ꯔꯥꯏꯁ.
ꯑꯦꯟꯇꯔꯞꯔꯥꯏꯖ ꯁ꯭ꯇꯦꯟꯗꯔꯗ ꯑꯃꯁꯨꯡ ꯹꯹% ꯄ꯭ꯌꯨꯔꯤꯇꯤ.
ꯑꯩꯈꯣꯌꯅꯥ ꯃꯦꯟꯌꯨꯐꯦꯀꯆꯔꯔꯅꯤ ꯑꯃꯁꯨꯡ ꯐꯦꯛꯇꯔꯤꯒꯤ ꯃꯃꯂꯒꯥ ꯂꯣꯌꯅꯅꯥ ꯑꯋꯥꯡꯕꯥ ꯊꯥꯛꯀꯤ ꯄꯣꯠꯊꯣꯀꯁꯤꯡ ꯄꯤꯕꯥ ꯉꯃꯒꯅꯤ.
ꯁꯦꯐ ꯑꯃꯁꯨꯡ ꯐꯥꯁ꯭ꯠ ꯗꯦꯂꯤꯕꯔꯤ
꯱)ꯄꯥꯔꯁꯦꯜ ꯑꯁꯤ ꯄꯦꯃꯦꯟꯇ ꯇꯧꯔꯕꯥ ꯃꯇꯨꯡꯗꯥ ꯊꯕꯛ ꯅꯨꯃꯤꯠ ꯳ꯗꯥ ꯊꯥꯕꯥ ꯌꯥꯏ. ꯇ꯭ꯔꯦꯀꯤꯡ ꯅꯝꯕꯔ ꯂꯩꯕꯥ.
꯲)ꯁꯦꯛꯌꯨꯔ ꯑꯃꯁꯨꯡ ꯗꯤꯁꯛꯔꯤꯠ ꯁꯤꯄꯃꯦꯟꯇ. ꯅꯍꯥꯛꯅꯥ ꯈꯅꯕꯒꯤꯗꯃꯛ ꯇꯣꯉꯥꯟ ꯇꯣꯉꯥꯅꯕꯥ ꯇ꯭ꯔꯥꯟꯁꯄꯣꯔꯇꯦꯁꯟ ꯃꯦꯊꯗꯁꯤꯡ.
꯳)ꯀꯁ꯭ꯇꯃꯁ ꯄꯥꯁ ꯔꯦꯠ ꯹꯹%꯫
ꯑꯦꯐ.ꯑꯦ.ꯀ꯭ꯌꯨ.
ꯍꯠ ꯇꯦꯒꯁ: ꯇꯤꯔꯖꯦꯄꯦꯇꯤꯗ ꯳꯰ꯑꯦꯝ.ꯖꯤ.꯱꯰ ꯋꯥꯏꯂꯁ ꯑꯣꯖꯟ ꯍꯟꯊꯕꯥ ꯀꯝꯄꯥꯎꯟꯗ, ꯆꯥꯏꯅꯥ ꯇꯤꯔꯖꯦꯄꯦꯇꯤꯗ ꯳꯰ꯑꯦꯝ.ꯖꯤ ꯱꯰ ꯋꯥꯏꯂꯁ ꯑꯣꯖꯟ ꯍꯟꯊꯕꯥ ꯀꯝꯄꯥꯎꯟꯗ ꯃꯦꯟꯌꯨꯐꯦꯀꯆꯔꯔꯁꯤꯡ, ꯁꯞꯂꯥꯏꯌꯔꯁꯤꯡ, ꯐꯦꯛꯇꯔꯤ